• ARTICLE_TITLE


    By H. Mirzo. Hebrew College. 2018.

    The pectoral and scapular regions 75 33 The axilla Pectoralis minor Pectoralis major Short head of biceps Trapezius Coracobrachialis Clavicle Subclavius Long head Lateral cord of biceps Axillary artery Clavipectoral (tendon) Medial cord fascia Axillary vein Axillary space Posterior cord Latissimus Pectoralis dorsi (tendon) minor Chest wall Pectoralis major Fascial floor of axilla Serratus anterior Subscapularis Fig propecia 5mg mastercard. The posterior cord is hidden behind the axillary artery 76 Upper limb The major nerves and vessels supplying and draining the upper limb anastomosis cheap propecia 5 mg on-line. It compensates for compromised flow that may occur due pass through the axilla. The principal arteries involved are the The axilla is a three-sided pyramid. Its apex is the small region suprascapular, from the third part of the subclavian artery, and the sub- between the 1st rib, the clavicle and the scapula through which the scapular, from the third part of the axillary artery with contributions major nerves and vessels pass. The walls of the axilla are composed as follows: • The axillary vein: is formed by the confluence of the venae comit- • The anterior wall is made up from the pectoralis major and minor antes of the axillary artery and the basilic vein (p. It becomes the muscles and the clavipectoral fascia. The named tributar- • The posterior wall is made up of the subscapularis, teres major and ies of the axillary vein correspond to those of the axillary artery. Running downwards from above are the corachobrachialis and In breast cancer surgery the axillary lymph nodes are cleared rou- short head of biceps as well as the long head of biceps in the intertuber- tinely. During the dissection for this procedure one must clearly iden- cular sulcus. Injury to the thoracodorsal nerve results in paralysis The contents of the axilla (Figs 33. Injury to the long thoracic nerve causes paralysis of • The axillary artery: an important anastomosis exists between the serratus anterior resulting in weakened arm abduction. On clinical subclavian artery and third part of the axillary arteryathe scapular examination the latter injury results in winging of the scapula. The axilla 77 34 The shoulder (gleno-humeral) joint Coracoclavicular Coraco-acromial ligament ligament Subacromial bursa Long head Acromion of biceps Supraspinatus Subscapularis Subscapular Infraspinatus bursa Glenoid fossa Teres minor Capsular ligament Long head of triceps Fig. It is formed by the articulation of the humeral head with the shallow glenoid fossa of the scapula (see p. The Shoulder movements glenoid is slightly deepened by a fibrocartilaginous rimathe glenoid The shoulder is a ‘ball and socket’ joint allowing a wide range of move- labrum. Both articular surfaces are covered with hyaline cartilage. Much of this range is attributed to the articulation of the shallow • The capsule: of the shoulder joint is lax permitting a wide range of glenoid with a rounded humeral head. It is attached medially to the margins of the glenoid and lat- of compromised stability of the joint. The capsule is significantly strengthened • Flexion (0–90°): pectoralis major, coracobrachialis and deltoid by slips from the surrounding rotator cuff muscle tendons. The latter comprise: three gleno-humeral ligaments ior fibres). The main • External (lateral) rotators (0–55°): infraspinatus, teres minor and stability of the shoulder is afforded by the rotator cuff. Each of these muscles can perform its own function anterior. Almost simultan- • Bursae: two large bursae are associated with the shoulder joint. The eously the scapula is rotated so that the glenoid faces upwards; this subscapular bursa separates the shoulder capsule from the tendon of action is produced by the lower fibres of serratus anterior which are subscapularis which passes directly anterior to it. The subscapular inserted into the inferior angle of the scapula and by the trapezius which bursa communicates with the shoulder joint. The subacromial bursa pulls the lateral end of the spine of the scapula upwards and the medial separates the shoulder capsule from the coracoacromial ligament end downwards. The subacromial bursa does not communicate with the joint. The tendon of supraspinatus lies in the floor of the bursa. It surrounds the intracapsular tendon of biceps and extends dislocation as the head usually comes to lie anteriorly in the subcora- slightly beyond the transverse humeral ligament as a sheath.

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    In CATIE Phase 1 and 1B discount 5mg propecia overnight delivery, only one-third of enrolled patients were available for assessment at 12 months due to high discontinuation 227 rates propecia 5mg for sale. Differences in quality of life were not found between the groups for this secondary outcome measure. The degree of improvement from baseline was statistically significant in the olanzapine (P<0. The perphenazine and ziprasidone groups had similar improvements, but small sample sizes caused the results to be nonsignificant. The improvement with immediate-release quetiapine was very small. Examination of those who switched away from their originally assigned drug compared with those who stayed on their 228 originally assigned drug also did not find significant differences on QLS scores. In 2 shorter- term trials, no significant differences were found in improvement in total QLS score at 28 weeks 80 30 in trials comparing olanzapine with risperidone or olanzapine with ziprasidone. A 12-month naturalistic study (N=133) also assessed quality of life using the Quality of Life Enjoyment and 226 Satisfaction Questionnaire and again found no difference between olanzapine and risperidone. Clozapine and olanzapine were compared using the Subjective Well-being under 68 Neuroleptic Treatment (SWN) scale over a 26-week period. Both groups improved scores and olanzapine was found noninferior to clozapine. Two prospective observational studies have used the EQ-5D tool (formerly known as the EuroQol tool) to compare quality of life with atypical antipsychotics: the European SOHO study (N=9340) and the EFESO study of patients with first-episode schizophrenia (N=182). Both 174, 219 studies reported data after exposure of 6 months. After 6 months of treatment, olanzapine treatment resulted in numerically higher, but not statistically significant, scores compared with 219 risperidone or immediate-release quetiapine but was similar to clozapine. In patients with first- episode schizophrenia, olanzapine and risperidone resulted in very similar improvements in 174 quality of life, with no statistically significant differences. In a subgroup analysis of patients in the SOHO study who had not previously been treated with antipsychotic drugs (N=1033), olanzapine resulted in a significantly higher score at 6 months than risperidone (adjusted mean 229 difference, 3. It was not clear that this difference in visual analog scale rating was clinically important in patients with schizophrenia. After 36 months in the European SOHO study, differences in quality of life 182 between clozapine, olanzapine, immediate-release quetiapine, and risperidone were not found. Three studies of olanzapine and 2 of risperidone used the short form 36 (SF-36) to 230-235 measure quality of life in comparisons with conventional antipsychotics or placebo. These studies reported improvements in SF-36 scores over 6- to 52-week periods, but data were inadequate for indirect comparisons between olanzapine and risperidone. Atypical antipsychotic drugs Page 43 of 230 Final Report Update 3 Drug Effectiveness Review Project Functioning Social function Although the ability to maintain social relationships is a key goal for patients with schizophrenia, few studies have assessed social function as a specific and primary outcome measure. Social function outcomes that are objective and measured directly, such as employment status, are preferred to indirect or proxy measures by scales like the Social Function Scale (SFS), which is generally patient self-assessment of social ability. With the exception of the results from CATIE, the studies reporting social function outcomes were all fair quality and in none of these studies was social function a primary outcome. Other measures of social function resulted in mixed findings for the comparison of olanzapine and risperidone. In a 12-month effectiveness trial (N=108), no significant differences were seen between olanzapine and risperidone based on the Role Functioning Scale (RFS) or the 49 Social Adjustment Scale (SAS) – Severely Mentally Ill version. In contrast, in a 1-year open- label trial (N=235), improvement on the SFS was greater with olanzapine (+7. Differences on subscale items were found for occupation or employment, recreation, independence (performance), and social engagement or withdrawal. Using the Psychiatric Status You Currently Have (PSYCH) tool, a small, 6-month before-after study (N=42) compared olanzapine and risperidone and did not find statistically significant differences on financial dependence, impairment in performance of household duties, 146 relationship impairments (family and friends), or recreational activities. Those on olanzapine had improvement on occupational impairment scores while those on risperidone had decreased scores, but the difference did not reach statistical significance. Two 8-week trials of immediate-release quetiapine and risperidone (N=174 and 673) did not find differences in social outcomes (the Social Skills Performance Assessment [SSPA] tool was used in both trials and the Penn Emotional Acuity Test [PEAT] was used in the larger 88, 237 study). In a small 12-month trial (N=85) of olanzapine and immediate-release quetiapine, no significant differences were found between the drugs based on the Sickness Impact Profile (SIP) 83 or the Global Assessment of Functioning (GAF) scale after 12 months.

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    Because at baseline the 2 treatment groups differed nonsignificantly (at alpha=0 cheap propecia 1mg line. This post hoc analysis of subjects matched by FEV (% predicted) showed no significant difference in days to loss of control (1 P>0 propecia 5 mg online. The systematic review of chronic ipratropium bromide use in adults by Westby and 12 colleagues did not discuss this comparison explicitly, although this comparison was compatible with their inclusion criteria. It is unclear if they did not identify studies comparing ipratropium bromide plus albuterol with ipratropium bromide, or if they did not include this comparison. Pediatric asthma We identified no studies comparing the effect of ipratropium bromide with and without albuterol on control of asthma in children. Albuterol compared with pirbuterol Demographic and study characteristics are summarized in Table 7. Of the 3 studies (in 4 publications) that provided direct comparative data on these 14, 15, 67, 68 14, 15 67 drugs, 2 were of poor quality, and 1 was of fair quality. None of these studies provided data on effectiveness outcomes. Albuterol compared with fenoterol: Comparisons relevant to Canada Only 1 of the 24 head-to-head studies identified comparing albuterol with fenoterol reported 21 effectiveness outcomes for asthma. Albuterol compared with terbutaline: Comparisons relevant to Canada Adult asthma Demographic and study characteristics are summarized in Table 10 and effectiveness outcomes in Table 11. Use of rescue medications was examined and found to be similar in 2 poor-quality trials. In an adult asthma population 19 Gioulekas and others did not find a significant difference in use of rescue medication. In adults with asthma, symptom scores did not differ between albuterol and terbutaline in 13, 19, 22 3 studies (2 poor- and 1 fair-quality). In a fourth (poor-quality) randomized controlled trial 80 of 159 adults with asthma, the mean daytime asthma symptom score (P<0. Quick-relief medications for asthma Page 22 of 113 Final Report Update 1 Drug Effectiveness Review Project Pediatric asthma In pediatric asthma there was no significant difference in symptoms between the 2 70, 77, 79 77 drugs and respiratory rate decreased after both treatments. In exercise-induced asthma in a pediatric population, the only effectiveness outcome reported was the need for aminophylline treatment. Fenoterol compared with terbutaline: Comparisons relevant to Canada Adult asthma Demographic and study characteristics are summarized in Table 12. There was no difference in patient 97 preference between the 2 drugs in another study. Fenoterol compared with ipratropium bromide: Comparisons relevant to Canada Adult asthma There were no data in adults. Pediatric asthma 9 The Cochrane review by McDonald and colleagues included a study comparing fenoterol 0. After more than 1 week no significant difference in symptom scores was seen in children with mild stable 104 asthma. We did not identify any additional studies for this comparison. Fenoterol plus ipratropium bromide compared with fenoterol: Comparisons relevant to Canada Adult asthma There were no data in adults. Pediatric asthma 9 The Cochrane review by McDonald and colleagues included 1 small trial that compared 105 fenoterol plus ipratropium bromide with fenoterol monotherapy. However, McDonald and colleagues did not identify sufficient data in the primary study to draw conclusions on comparative effectiveness. Pirbuterol compared with terbutaline: Comparisons relevant to Canada We identified no studies comparing pirbuterol with terbutaline in asthma. Quick-relief medications for asthma Page 23 of 113 Final Report Update 1 Drug Effectiveness Review Project Safety Key Question 2. What are the comparative incidence and severity of adverse events reported from using quick-relief medications to treat outpatients with bronchospasm due to asthma or to prevent or treat exercise-induced bronchospasm? Overview of adverse events Withdrawal rates are presented in Table 14. Adverse events related to sympathomimetic side effects are expected with these medications and are discussed below. There was also a broad range of gastrointestinal, musculoskeletal, and other miscellaneous adverse events.

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    Obviously discount propecia 1mg online, such thoughts do not always play a role in clinical reality propecia 5mg free shipping. In an analysis in Great Britain 34% out of 694 patients remained on a virologically unsuccessful combination for over 6 months. Factors associated with an early switch were low CD4 T cells, a high viral load and older age (Lee 2008). To date, only a few randomized trials have investigated strategies in patients in whom several ART combinations have failed: either the patients change immediately or when the viral load reaches a certain level (early versus deferred switch). The preliminary results of some small randomized studies indicate that even in such cases one can wait a short time (Nasta 2006, Tenorio 2009). It seems difficult to recruit physicians and patients to participate in such strategy trials. When to switch 211 Arguments for a rapid switch Arguments for a later switch in the case of virologic failure in the case of virologic failure The virus becomes incapable of generating New therapies bear the risk of new toxicities/ more resistance intolerance, which can lead to a termination of therapy Options are maintained Most patients are immunologically stable for a long time with low viremia (clinically) The switch is more successful with Replication fitness is reduced on failing treatment less resistance The lower the viral load at time of switch, Resistance testing is often not possible with low the better the response to the new therapy viral load, even though they are there, so you may switch “blindly” The following regimens do not have It is sometimes difficult to explain to the patient to be as complex as the present one – why change of a well-tolerated and simple some things can be simplified (QD, no more regimen is necessary d4T/ddI, etc. In the prospective Johns Hopkins Cohort there was no association between a deferral of ART modification and mortality in the course of treatment in patients on a PI showing virologic failure (Petersen 2008). This is why in the TITAN Study, the number of acquired PI mutations had no effect on the success of darunavir/r, although it did play a role for lopinavir/r (De Meyer 2008). In cases of clinical treatment failure (disease progression) or immunological failure (stagnation or decrease in the level of CD4 T cells) where the viral load remains below 50 copies/ml, the value of a change in therapy is unclear. Some combinations such as TDF+ddI are clearly unfavorable for immunological reconstitution (Negredo 2004). This may also be the case for AZT-containing regimens; such combinations should be changed. It is important that when virologic failure occurs, the individual situation of the patient is carefully analyzed. In particular, several questions need to be addressed: What are the reasons for the measurable viral load? A viral load above 50 copies/ml does not necessarily mean that resistance mutations have developed. A frequent cause may be a blip (see section on Goals and Principles of ART). These transient and, almost always, small increases in viral load usually have no relevance. However, a measurable viral load may be due to treatment failure. It may indicate insufficient plasma drug levels (measure these if possible). This may be due to drug malabsorp- tion, drug interactions or simply insufficient dosing (e. Any difficulties related to the regimen should be openly addressed. The risks of resistance development as a result of non-compliance should be reiter- ated. If plasma levels are sufficient and viral load remains detectable (monitor blips at short intervals – within a few weeks), treatment should be changed as soon as possible. NNRTI regimens are extremely sen- sitive, and cross-resistance can develop particularly rapidly for the whole class. A prompt change in therapy is more vital than with the other drug classes. Delaying 212 ART this by even a few days or weeks may be too long. Rapid development of resistance can also be expected with 3TC/FTC and probably with the integrase inhibitor ralte- gravir. A PI-containing regimen without an NNRTI may allow a little more time, but the credo still applies. The higher the viral load at the time of modification, the lower the chance of success. What options does the patient have, and what are the consequences of the change in therapy? The more options that remain available the sooner they should be utilized. Therapy can sometimes be intensified quite easily (e.

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